How to pronounce“telomeres”in English

telomeres as if it were a lucky fact because it allowed testing hypotheses

telomeres was a proof of concept right that paper was a proof of concept that the toolkit in question works um

It even lengthens your telomeres, which in your brain, can help prevent-- it can help prevent the slowdown of cell rejuvenation.

Let's talk about telomeres now.

And as our telomeres get shorter, our lives get shorter, and the risk of premature death from heart disease, diabetes, most forms of cancer,

You can worry about telomeres. Lots of people talk about telomeres, I think partly because they like the word.

lengthens art telomeres so those folks were interested in uh bringing about a halt to the lengthening of telomeres in order to

Ultra long telomeres now what this implied though as you read is that our reading protocols generate lengthening of

enzyme that lengthens telomeres um but anyway she's a heavy hitter in the academic world I don't know exactly what her purpose

She was doing early work on telomeres, actually studying pond scum, because it was cheap and readily available, and

this cellular replication and control telomeres.

Talk to us about what are telomeres, first of all, for those in the YouTube land who may not know yet?

appears to have greatly elongated the telomeres of laboratory mice with their telomeric Fail-Safe effectively disabled these animals are unreliable models of

that laboratory mice have anomalously long telomeres and that wild mice don't have long telomeres I asked her where she was going to publish that result so

that this particular the length of the telomeres is not a strong variable for the conclusions for for the drug development and for the conclusions that

the understanding of the functioning of telomeres is it's Central do you feel like you you've been as a young graduate student do you think

So for example, your telomeres will shrink over time.

But one thing that was really striking is that his telomeres actually got longer in space, so you can see here.

Well, telomeres are-- the analogy that Liz Blackburn often gives is they're like plastic tips on the ends of your shoelace to keep your shoelace from unraveling.

I don't know if you've heard of telomeres.

We have a clock in our cells called telomeres, they get shorter and shorter after every cell reproduction, after a certain point they simply unravel the chromosomes of the cell and the

the basic takeaway like basically saying that the length of these telomeres is an important variable to consider well let's put it this way I think there was

a reason that the world of scientists who was working on telomeres did not block did not spot the plyotropic relationship that uh was the key

the result was that mice have very long telomeres but they do not have very long lives now we can talk about what the actual

And as we get older, our telomeres tend to get shorter.

It was how the women were reacting to it that determined its effect on their telomeres.

It's still the only control study showing that any intervention can actually make your telomeres longer.

You know, the ends of the DNA -- telomeres.

counteract cancer and the folks who were studying the senescence process were interested in lengthening telomeres in order to generate greater repair

project but as a favor she was doing another project that involved telomeres and she needed samples that I could get a hold of because of the Museum of

Here, too, lead to higher telomeres for the twins that were on Mount Everest, as well as now 11 other astronauts.

There were lots of advances being made, including the discovery of telomeres, which are repeating segments at the ends of chromosomes that essentially protect

And what findings did you show in terms of the impact of these kind of changes on telomeres themselves?

And after five years, the telomeres got 10% longer, whereas they got shorter in the control group.

It sounds kind of sexy and science-y. The problem with telomeres is that actually in some species the telomeres get longer as they get older.

his telomeres got longer in space and so this is really surprising because we thought the

looked now in 59 other astronauts and in every astronaut that we've looked at their telomeres get longer in space.

and everybody else was repeating it didn't turn out to be the case many Laboratories had established that mice had Ultra long telomeres

protocols that generated these mice and what that would predict is that the mice that have long telomeres would be laboratory mice and that wild mice would

And so far we've seen this seems to be a very consistent feature of spaceflight, is that your telomeres will get longer,

Then in 2009, she, Blackburn, and a third scientist who had worked on the early work of telomeres won the Nobel Prize in Physiology and Medicine.

We've found it to reverse heart disease, diabetes, prostate cancer, change your gene expression, lengthen your telomeres.

And so across 500 genes, both in terms of up-regulating good ones and down-regulating bad ones-- we'll get to telomeres in a second,

with Alzheimer's or kids with autism-- the more stress they felt and the longer they felt that way, the shorter their telomeres were.

And so I thought, well, OK, if bad things make your genes shorter-- I mean, your telomeres shorter-- maybe good things make them longer.

But stem cells express an enzyme called telomerase, which will extend the telomeres on the cells.

Some of you are probably aware of it, but one simple, simple, simple idea is the telomeres.

hallmarks of aging which are really it's a it's a word for causes of aging so that you probably have heard of some of these your listeners will have a loss of telomeres

So in this case, we looked at genetic changes, epigenetic changes, RNA changes, protein changes, chromatin and antibody titers, B cell, T cells, telomeres,