And it may not be good for their child, the baby, when it's born if, for example, they have obesity or type 2 diabetes .Right. Right. So you sort of alluded to the conventional medical wisdom sometimes changes.
Fatty liver. Certain things like, oh, increase in diabetes . The things that were diseases that had been described, they're all Some of them are old diseases that haveincreased in incidence, but some of them for the first time, fatty liver was first described, non-alcoholic fatty
wonderful idea. Uh if you're a woman that has a type 2 diabetes or PMOS, something like that, a temporary clawback of carbohydrates isfantastic for improving insulin insensitivity, glucose disposal, um
clinic, I saw two people under the age of 25 who had poorly controlled diabetes , and one of them was too heavy for me actually to weigh.And this situation is completely new.
Yeah. So, eight forms of cancer uh are strongly associated uh with diabetes . I want to just define that term diabetes , because I think I went through a lot of my life assuming thatdiabetes was a disease that some people are born with, and because I didn't have it, I thought I don't need to worry
diabetes . I want to just define that term diabetes , because I think I went through a lot of my life assuming thatdiabetes was a disease that some people are born with, and because I didn't have it, I thought I don't need to worryabout that. really important. Yeah. So, first of all, there's type 1 diabetes and type 2.
Okay. How about we wait for the 10 years and Steven until Steven you've got type 2 diabetes and then you go low carb.At that point, if I can get you early, I've got a 73% chance of you having a normal blood sugar.
All the heart disease is very much a disease of age, but the usual things smoking, being overweight, high-blood pressure, cholesterol, lack of exercise, diabetes is a big one that's increasing over time in all the populations as well.Alcohol unfortunately, yes, it is still some evidence a little bit of alcohol could be beneficial, but basically, that sort of amount
One thing that I want to sort of point out, and a point that I make, is that in rural areas that have agrarian lifestyles, diabetes rates are actually quite low, right?But subsistence farming isn't a great way to live for a lot of reasons.
Or we need to swim more. Diabetes is on the rise, but there's some hopes there.
Make something more beautiful. diabetes in India. And he's just asked me to come over, and we'll see where it goes.
The other number I want to tell you about is not reported on nearly all cholesterol panels, but I think is one of the most important ratios you Diabetes is in my family.
In eager medical student fashion, we routed off the usual suspects. Diabetes , high blood pressure, heart disease, old age, smoking, and high cholesterol." I ran out of fingers there."When it was my turn again, Dr. Wilson indicated that there was one important risk factor we had yet to mention.
It was your mind. diabetes , and heart disease.
So diabetes . Most of you will know what diabetes is, but just the start of the basics. Diabetes is a condition where patients lose the ability to adjust their blood sugar.And there are two main types of diabetes -- there are several subtypes-- but two main types.
That's how they originally discovered it when Banting and Best were working on this. Diabetes is a dangerous condition to have overall.Kidney failure is a problem-- 25 times more risk than the general population.
And life expectancy for patients with diabetes is at least 10 years shorter than the rest of the world without diabetes . Diabetes is the leading cause of vision loss in working age adults.It's the commonest cause of end stage kidney failure, and of non-traumatic lower limb amputations, because the blood vessels basically become destroyed when the body's glucose becomes awry.
And when we've tested these in our mouse models and our pig models, we find that these caspase inhibitors can reduce the tiny number of islets needed diabetes , that have chronic type I diabetes , and also those that have type 2 diabetes -- the entire spectrum of diabetes .
And when we've tested these in our mouse models and our pig models, we find that these caspase inhibitors can reduce the tiny number of islets needed diabetes . So there's a lot of things happening.
This is-- we see the obesity epidemic following the same lines as the growth in driving. Diabetes , asthma from air pollution, a lot of these are growing tremendously, and a lot of it related to lack of physical activity, air pollution from vehicles.And in almost all of these slides that you see, there is a layer that the folks most impacted are low-income,
your age group, your peer group, because as you likely know, as we get older, our sleep deteriorates, and so you want to have a group that you compare with. diabetes or other named diseases.
last 10 years that number alone has doubled what do we spend on type two diabetes five back in 2001 we spent 7 billion dollar on drugs for type 2diabetes today we spend 13 B ion Dollar on drugs for type 2 diabetes again
diabetes five back in 2001 we spent 7 billion dollar on drugs for type 2diabetes today we spend 13 B ion Dollar on drugs for type 2 diabetes againweight obesity being the key determinant in susceptible individuals to the onset
diabetes killing someone, right?
diabetes , clinical depression, high blood pressure, domestic abuse.
But subsistence farming isn't a great way to live for a lot of reasons. But diabetes is not very high. So people tend to have a lot of physical activity, not a lot of calories, not a lot of trans fats or saturated fats.
So people tend to have a lot of physical activity, not a lot of calories, not a lot of trans fats or saturated fats. And diabetes rates are low. But then when they go to more of an urban lifestyle with eating Big Macs and fries, so high fat diets, as you
So diabetes , if we reverse back to 1980s, was one fourth of what it is now.
Because diabetes is a risk factor for heart disease and diabetes prevalence is so much higher in South Asians, particularly among young Indian men.
And diabetes rates are low.
if diabetes came up and you discussed that?
In diabetes , we have a pump and you have the glucose monitor, so you can kind of titrate your insulin treatment depending
two diabetes . So you don't want glucose spikes with your food. So he mapped all these microbes and all these food types.
So diabetes is up 60% in the last 10 years.
And diabetes isn't even in the mix anymore.
the diabetes epidemic, the heart disease epidemic, probably partly the Alzheimer's epidemic as well.
from diabetes .
And I'll try and take you along that journey of cutting edge islet and stem cell transplant treatments in the clinic for diabetes as we move forward today. So diabetes . Most of you will know what diabetes is, but just the start of the basics. Diabetes is a condition where patients lose the ability to adjust their blood sugar.
And therefore when they receive insulin, or the pancreas is making insulin, the body's needs for insulin are basically what the pancreas can release is insufficient. So diabetes is a very common condition. There are about 381 million people with diabetes in the world today, based on the world estimates from the Diabetes Federation 2013.
with diabetes or heart failure, a burden to the public.
with diabetes or heart failure, a burden to the public.
or diabetes , we rarely see fitness thrown into the mix and so it's nice to see a trial that's not so siloed.
a diabetes clinic at the University of the West Indies, and in the early 70s reported that a third of the women over 25 were obese and that obesity reached what he called "monstrous
which is important for diabetes -- you can also pick up with a smartwatch, thanks to the skin conductance measure on these things.
And we have a diabetes epidemic going on that's worse than the COVID pandemic.
with type 2 diabetes ?
her son. And since her son was born, she has not been able to go back to sleep. She had gestational diabetes . Like, she's doing everything perfectly. She knows everything there is to know. She's
And in fact, type 2 diabetes had a different name. We've had to change the name because of the epidemic. Used to be called maturity-onset diabetes . That meant old people. Right? Now we call it type 2 diabetes because we have to include so many young people. It's really, really serious
But you don't even know. You're talking about what's in my mind. Why are we waiting until you actually have all the problems of type 2 diabetes ? So, since 2013, I've got hundreds of patients, and I'm monitoring the baseline and latest follow-up. So, I what happens to them? It's really important.
So, the part of my payment was to do with all the patients having in this case metformin, the most commonly used drug for type 2 diabetes . Part of your payment? Yep. Yeah, how would you mean?