How to pronounce“epigenomic”in English

epigenomic map in that particular case it was mesenchymal stem cells so these are the progenitor cells

epigenetics epigenomics and uh some of the incredible research you're doing truly an honor thanks so much for talking

are the epigenomic alterations at the level of gene regulatory elements where that genetic variant perturbs the control region nearby that effect is

to it there's epigenomics there's expression there's a whole series of things but basically it's four letters making all life forms as we understand

to the epigenomics to the transcriptomics to the cellular readouts using these sort of high throughput perturbation technology that i'm talking

and then in this roadmap epigenomics paper you know a few years after that but basically that

and enhancers to their target genes using epigenomics and regulatory genomics so through the years we've basically built

But if we scratch the genome and cause epigenomic changes, we can age the mouse 50% faster.

across 127 different tissues and samples with dozens of epigenomic marks measured in you know hundreds of donors so what we've

obviously the brain so we had basically this roadmap epigenomics consortium view of the human epigenome

tissues sort of the the next generation of the epigenomics roadmap which we're now called epimap

come together and act in specific tissues using epigenomics how do you link regulators to enhancers

on your experiences there's a whole field called uh epigenomics which is or epi epigenetics i should say which is about

this genetic variation with molecular variation at the expression level of the genes at the epigenomic level

constitutes the genetics of that gene but also of course all of the epigenomics of that gene it's fascinating that the

It's starting to move around in so-called Waddington landscape space, or epigenomic space, and it's becoming a different type of cell.

trillion dna breaks every day and imagine that over 80 years what damage that does to our epigenomic information

but basically we were for the first time able to show that specific chromatin states specific epigenomic states in that case enhancers

taking all of these non-coding variants that are sitting outside proteins and then figuring out what are the epigenomic enrichments and the reason for that you know

for all of them basically that for every single disease that we've looked at we have found an epigenomic enrichment how do you do that

politician any one of these things is all coded in this four-letter code there's subtleties to it there's epigenomics there's expression there's a

No wonder we start to lose the function of our retina, no wonder we start to forget things if our cells don't maintain their epigenomic information.

is earlier on in the pipeline as early as possible it's it's a trade-off if you go very early on in the pipeline now each of these epigenomic alterations

the epigenome and that is the you know sort of the layer that sits on top of the dna and causes the genes to express differently