How to pronounce “epigenome” in English

This epigenome is useless, but it has to be engineered that way because the epigenome needs to respond very quickly to the environment.

It's the epigenome. The epigenome is the information we get transferred from cell to cell, from

also important for this epigenome, they don't all go back to where they started.

And that's the epigenome, which I'm showing you as these green proteins that wrap up the DNA.

And the epigenome, I believe, is the reason that we age.

and the epigenome is very stable.

But the epigenome can change moment to moment.

It's called the epigenome.

is the epigenome.

And the epigenome is actually something that has been studied in science for quite a few decades now, but the actual program or system itself is so complex

So the epigenome is usually written in kind of chemical modifications.

And the epigenome is a layer of chemistry that sits on top of your genome.

And the epigenome is highly dynamic- these are things that can go, we think, in both directions.

One way of thinking of the epigenome is it's the software of our cells, and the genome is the computer or the underlying code.

It's coming from the epigenome.

The other two are your epigenome which is switches on your DNA that get flipped.

But really what this reprogramming of the epigenome tells us is that this is a lot more kind of modifiable

But really what this reprogramming of the epigenome tells us is that this is a lot more modifiable and elastic than we originally knew.

when we look at the epigenome.

So here's a cartoon of what the epigenome looks like.

composite of different cell types when it's born is the epigenome.

The thing that's most exciting to me about studying the epigenome and the epigenetic clock is that this is actually a really powerful tool

And we know that there are changes to this epigenome as you get older, and so by measuring the changes in the epigenome

But what we've messed up is their epigenomes.

And that's the epigenome. These chemicals that turn genes on and off is the epigenome.

is the control systems, the epigenome.

The problem is that with aging, the epigenome becomes remodeled either due to stress or random errors.

So one hypothesis is if you can actually remodel or reprogram the epigenome to a younger state, that you actually might prevent some of these cells

A lot of the changes that cells undergo with aging including changes to the epigenome, give rise to some diseases like cancer.

I stands for inducible changes to the epigenome.

It means-- like epidermis is the layer of skin that's on top of the dermis- the epigenome is the chemical matrix of chemical tags that lie atop the genome.

Like many of the things we've talked about in terms of aging, the epigenome, again, is highly dynamic.

A lot of the changes that cells undergo with aging, including changes to the epigenome, actually give rise to some diseases like cancer.

And we think some of this might be due to the types of changes that are measured when we look at the epigenome.

If you think of your DNA as that instruction manual, then the epigenome is the notes in the margin, it's the little sticky notes

The problem is that, with aging, the epigenome becomes remodeled, either due to stress, or random errors, and what this produces is

So across all these different omics, which is the genome, the microbiome, the epigenome, transcriptome, all these metabolites, we could see things moving and shifting with each other.

All the way down to the lowest levels, you have things like changes to the expression of genes with the epigenome.

If that's true in our bodies, we could take the old epigenome and reset it to be young again.

And in fact, if we look at those mice, even though we've just disrupted the epigenome, they have all of those hallmarks,

It talked to our epigenome and it transforms our biology in a moment

Every cell in our body has a very specific function, and this function is really dictated by the epigenome.

So even though the cells in your skin and the cells and your brain have essentially the exact same DNA, what makes them different is the epigenome;

Every cell in our body has a very specific function, and this function is really dictated by the epigenome.