which has revolutionized the treatment of patients with arrhythmic heart disease. Transplantation has improved a lot with systems for taking care of the heart once the donor heart as it's traveling to the patient,but it's limited by the number of donors, which in fact, is getting lower because of safety advances in traffic and things
But after two or three times, I got it. So organ transplantation is a fascinating area.
As soon as the blood glucose drops below a certain level, then the brain can no longer function. So islet cell transplantation has been around since the 1970s experimentally. And first trials in patients happened in the 1980s.
complex. And what it does is it says this is me, and if another cell expresses differences, it's not me, and your body tries to kill it. We're doing the heterochromatin transplantation of young MSCs to older mice, and we're going to see if it improves their health span.
I'm now going to explain and tell you the story about transportation shortly. But really our indications for islet transplantation have been to try to reduce this risk of hypoglycemia, reducing the risk of lows in patients that are needing insulin.
These trials are now completed or undergoing a very detailed analysis with the FDA, and very likely, these two trials will lead to the FD awarding a biological license for islet transplantation , allowing Medicare, Medicaid, and third party payers to potentially reimburse islet transplant in the US, which has been a major limiting factor in terms of the numbers of cell transplants done in the US.
And when we've tested these in our mouse models and our pig models, we find that these caspase inhibitors can reduce the tiny number of islets needed So we recognize today that islet transplantation , the way it is today, because patients need immunosuppression, because there is a shortage of organ
I talk about a curative therapy that comes from a root that was discovered in China, experiments in dogs, in beagles, that led to the modern miracle of bone marrow transplantation . I also describe the unflagging research efforts of one man, whose name is Brian Druker, whom I actually know,
can cause severe and intractable and often fatal cases of diarrhea um C uh there's been a trial of fecal transplantation for custm defil uh in that trial people with the condition who were given standard antibiotics some 27% of them were cured whereas feal
But certainly, it started a lot of enthusiasm-- a lot of potential-- for obesity metabolic syndrome. And there are many studies going on with fecal microbial transplantation , antibiotic treatment, and so forth. Why would these microbes be able to talk to us?
But after two or three times, I got it. Well, transplantation is a funny subject.
He's currently continuing this research at the University of Alberta in Edmonton, Canada. And he also holds the Canadian Research Chair in transplantation and regenerative medicine. Dr. Shapiro's received quite a lot of awards, including a Hunterian medal from the Royal College of Surgeons of England.
This will happen again after an islet transparent to the new cells, unless the anti-rejection drugs are given. So there's been real progress in islet cell transplantation . I'll explain that to you.
And when we've tested these in our mouse models and our pig models, we find that these caspase inhibitors can reduce the tiny number of islets needed And here's one that we're testing out for pancreas transplantation .
And when we've tested these in our mouse models and our pig models, we find that these caspase inhibitors can reduce the tiny number of islets needed I think we could apply this very easily also in liver transplantation , maybe join the pancreas islet isolation.
Elles ont été accompagnées par la FRM. Parmi les plus connues vous avez le cœur, transplantation cardiaque. Le Professeur Cabrol est extrêmement connu, le reste est moins connu parce que ça c'est un truc que je dis et qui me choque et qui fait partie de mon engagement c'est que,
And when we've tested these in our mouse models and our pig models, we find that these caspase inhibitors can reduce the tiny number of islets needed And this is going to I think really revolutionize all areas of transplantation .
And when we've tested these in our mouse models and our pig models, we find that these caspase inhibitors can reduce the tiny number of islets needed A guy was telling me about the use of these in lung transplantation .
We motivated them. Glad to share with your, friends. Right now, we are getting a pair of eyes almost every day for corneal transplantation . For all these activities, these service activities, for it to be perpetuated, we need to have a sustainable model.
Don't mention Deloreans. So what we do, it's called a heterochronic transplantation . And so you just preserve the cells.
We haven't got to Nirvana yet, but we're trying to get there along the plateau of productivity. And still I think if you can read and you can Google lots of negative reviews on islet transplantation , because I think the knowledge in this area probably hasn't reached all of the community.
as we progressed i think the good the good thing about cystic fibrosis is that it's the kind of disease where you can sort of think about taking the bad part out and putting in a new and that was the idea of transplantation that gave us tremendous hope for the future and the next slide is kind of graphic but it's a very complex
I'm really excited to introduce Dr. James Shapiro. Dr. Shapiro's been working on diabetes research for a long time, and in particular he's credited with developing the Edmonton Protocol for human islet cell transplantation , which was published in the New England Journal of Medicine in the year 2000.