How to pronounce“protonation”in English
When the electrons move down from the oxygen, the ring cleaves to leave an ester group at one end of the molecule.
At the other end, we have our leaving group, and the protonation at nitrogen leaves us with an amide.
So, overall, Dr. Sheehan used a conjugate addition reaction to add the sulfur atom needed for the penicillin ring!
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Definitions of “protonation”
The addition of a proton (hydrogen ion) to an atom, molecule or ion, normally to generate a cation.
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