How to pronounce“deprotonate”in English

So if we deprotonate an alcohol, we make an alkoxide, the negatively charged conjugate base, which is an excellent nucleophile.

The sodium hydride can deprotonate ethanol, generating an ethoxide ion.

That's why we can deprotonate the hydrogen atom on a terminal alkyne.

Most basic nucleophiles tend to deprotonate carboxylic acids!

When the alpha hydrogen is deprotonated, the anion that forms is resonance-stabilized.

And then a second water molecule deprotonates the oxonium ion… forming an alcohol group in the final products.

After this, the water deprotonates the carbonyl oxygen, and we're left with a carboxylic acid as our other product.