Separately, surrounding these plaques, and also in other areas of the brain that don't have plaques, there are these other structures called tangles . Tangles are an accumulation of a completely different protein called the tau protein.And it aggregates inside of neurons, whereas plaques are outside of neurons.
relationship for sure. But, like I said earlier, it's really well understood. called tangles and another type outside called plaques.
We've come a long way in biology in that time. called tangles -- molecular junk outside neurons called plaques.
issues and some number of them have never even heard of the singer probably a smaller number I'm just get tangled up I think that's a very interesting point in terms of um at least part of the signal that we get from search point
because the pain doesn't stop type of work right it's bureaucracy it's pointless meetings it's paperwork it's processes that tangle you up I mean it's like it just is there and I want to give you two ways for you to think about and remember bad work here's a question does anybody know what this animal is
It isn't until the sun is setting and they've finished roasting a magpie that Lolo finally asks the question that's been on his mind ever since Travis's sun-baked face came out of the tangle . It goes against etiquette, but he can't help himself. He picks magpie out of his teeth and says, "I thought you were workin' downriver." Travis glances sidelong at Lolo. And in that one suspicious uncertain look, Lolo sees that Travis has hit a lean patch. He's not smart like Lolo. He hasn't been reseeding. He's
I've been fighting off a cold here. The whole notion of our history being a kind of a tangle of strong passions fighting up against each other is fine as long as we're stable, as long as we don't have severe imbalances. But with this economic situation, what if our internal enemies decide they want to reenact something that's been supposedly gone for 150 years? And that's the situation.
Anyway, I did four years there. Back to Tanglewood-- so Tanglewood had this very elite, number one student orchestra in the country. So I auditioned in I think my first year at Indiana University.
Or worse, maybe not worse, but we would also-- when we were in trouble or struggling with something, and we needed a sane person to sort out the tanglements of our life, we would turn to our friends instead of our parents. Who had life experience, and who hopefully cared about our best interests.
So that's how I operate. But-- And Tanglewood is also-- Tanglewood I don't mind telling you.
relationship for sure. But, like I said earlier, it's really well understood. It's also tangles accumulating inside the cell, which was not targeted by the therapy.
But at this point, he's going to come back to Coimbatore and things will get very complicated. And Malathi's life and his life and Mrs. Ballen's life will all get tangled . But I'm going to stop right here and ask you if you have questions.
Kai scrambled to shore it up, but the next rushing wave tore her feet from under her. She went down in a tangle of limbs and foam. Waves and crosscurrents tossed her, tumbled her, and she spilled from the moat onto the beach.
He knelt to kiss his murdered brother, and the crowd closed in over him, breaking like water through a dam. People enveloped him in a tangle of interlocking limbs. He stayed down there, out of sight, under the bodies, for what seemed like minutes, amid the keening moan of the crowd.
She peered around the room. Her hair sat in a brutalized tangle at the top of hear head. 'You all done?' she asked.
It just sort of viscerally bothered me. I remember a deer who was tangled in a chain link fence in a neighbor's backyard, and also, on television, I was seeing wars and the violence humans were causing to each other, as well as what I had seen with the harm we were causing to the Earth and other animals.
Here's a ship's propeller tangled with a netting.
Now you didn't have immediate success right away. So talk me through the time at Tanglewood. I think you didn't get in on your first three tries.
And from there went on to Tangled , Wreck It Ralph, Big Hero 6 and Zootopia.
So that's how I operate. And since we're announcing Tanglewood on Friday-- Thursday?
Revealing the Mysteries of Catalhoyuk," and "Tangled , An Archaeology of the Relationship
And still more boxes containing dense tangled snarls of cables and power adapters, that I would need if I ever wanted to make the technology work again.
And what do you know: those tangles are all over the brain.
spiritual life all became twisted in impossibly tangled at a early age and
You have to establish at the very beginning whether the tangle of symbols in front of you actually is writing.
collarbone is missing revealing strips of muscle and a tangle of blood vessels
It's one big ball of Christmas lights that's all tangled .
It's actually defined by what your brain looks like in the microscope after death. So there's these characteristic changes of plaques and tangles . These plaques are made up of a protein that we came to discover called the beta-amyloid protein.
And this is what he found. He was the first one to describe these plaques and tangles . So at this psychiatric conference in 1906, he presented this paper.
I think you didn't get in on your first three tries. And it was the fourth time that you got into Tanglewood, which is the Boston Symphony Orchestra. Well, my education went like this.
Yeah, I got tangled up.
So that's how I operate. She is going to be with us at Tanglewood.
And what's the optimal way to be tangled up with someone?
And the political news and the social news were very tangled up because if two families fell out, that could actually mean civil war.
He came to a high school thing at Tanglewood we did.
Alton Brown: I don't want to get tangled up in this big and I like ties, but I don't want to get tangled up and I also find that whenever I get a really, really nice regular
so what are the impacts of marine debris is tangled in FC many different kind of coffee with carbon fishing lines we're
happens where some of the amyloid plaque that builds up in the brain that can tangle and get entangled with our neurons,
So you had to be very careful when you interviewed him because he'd always tangle you in a little dispute there.
they're going to say about you and that's the kind of tangle we end up with when we discuss privacy I think we need
Lolo flails for his shotgun where it nestles in a scabbard at the camel's side. He forces Maggie to turn, shotgun half-drawn, barely holding onto his seat and swearing. A familiar face, tucked amongst the juniper tangle . "Goddamnit!" Lolo lets the shotgun drop back into its scabbard. "Jesus Christ, Travis. You scared the hell out of me." Travis grins. He emerges from amongst the juniper's silver bark rags, one hand on his gray fedora, the other on the reins as he guides his mule out of the trees. "Surprised?"
And when you do, the fibers form a tangled , layered structure.
So for me, even in the story "Tanglewood," Sam instructs Elise.
So yeah, our experiences are getting very much tangled up in-- and I kind of brought this one first because this is a tech company and a lot of things
Downstream of that is the accumulation of that tau protein. Remember, I told you about the tangles that you see in the brain. And eventually, that leads to neurodegeneration.
The optimistic view of this graph is look how resilient the brain is. It can withstand a lot of amyloid plaques and a lot of tau tangles before a patient exhibits the first symptom. So symptoms are long-delayed in time from the accumulation of the damage in the brain.
And namely, they get plaques and tangles like humans do.
Why? If you're going to be tangled up with all beings forever, then you better optimize your tangling up with him.
And yet, she is holding onto a very tangled , complicated, awful secret.
I mean, we have this tangled , contradictory, even schizophrenic relationship with animals.