How to pronounce “predisposition” in English

came up that was interesting is there are genetic markers that are linked to certainpredispositions. Which shouldn't be surprising at all to us, because we all know that all kinds of talent runs in families and wouldn't be the least bit surprising to us if a greatathlete father had a great athlete for child; or a great musician had a great musician for a child.

And so it's been fascinating that for LDL, the bad cholesterol, we put roughly-- at that point we had 3,000 members-- into five quintiles and came up witha genetic predisposition for having high LDL.And everyone mapped beautifully to their genetic predisposition, unless they were on a statin.

So it's not all that different.The kind of psychological predisposition I'm thinking of is well, because we're very social animals,we have a natural tendency to calculate debts to others, things that we owe to others because reciprocation

I think a panda bear is going to emerge from the tree and give me a big bear hug or something." How long do you think that ancestor actually survived?So the predisposition to negativity was something that was helpful for survival.That part of brain kind of got developed because we all have that.

And I personally thank you.carry some predispositions, genetically.

I've discovered over decades that humans are incredibly short-term oriented.And they have an enormous predisposition to optimism.They're looking for optimistic news in everything. They're looking to avoid unpleasantness. The idea that you can

So for an example of a disparity we know of, African-American women who are diagnosed with breast cancer are more likely to die than non-Hispanic white women.And that is not a genetic predisposition.That is because of these inequities that exist.

a genetic predisposition for having high LDL.And everyone mapped beautifully to their genetic predisposition, unless they were on a statin.So then how do we use that information to coach?

As we did research on that protein, it turns out it's linked to the function of the pancreas.So imagine if we understood genetic predisposition for pancreatic cancer.Not hard to do.

Anyway, I was really concerned.I thought maybe I would have a predisposition to it, given my mother's history.And I remember on several occasions really begging my surgeon.

And it's really interesting what Sergey says, because he is then-- he actually goes on in his blog to give specific example of how he might change his life due to learningabout this genetic mutation and the predisposition to Parkinson's.So there is some research showing that exercise may be protective against the development of / so I can only imagine that he has the common gym rat.

conditions. So the challenging thing is to be aware that these comfort foods are the worstIf you have a genetic predisposition for Alzheimer's disease and a lot of relatives with it, then I'll be particularly worried about the brain being

But he just stood there and just sang.So it have been a genetic predisposition and curiosity for that kind of stuff.

I couldn't do ramen every day.Male Presenter: Even though you had a predisposition for Japanese culture.Mark: Yes, yes. But not a predisposition for Japanese food.

And that's because I think that human nature is very much expressed in our social behavior.So I think that people have biological predispositions to act in certain ways towards others, and that the genetic basis and the neural, physiological, cognitive,behavioral mechanisms that control social behavior evolve by natural selection.

And I have a bit more of a predisposition toward that.

And what our scientists did is that we came up with a correlation network where we looked at someone's genetic predisposition.And then we found what were the signals to that genetic predisposition to metabolites, proteomics, clinical labs, gut microbiome.And for this paper the scientist just pulled out 32 different signals.

and how you approach individuals who already have a predisposition, or if you sort of see that as a separate strategy that is maybe over-utilized.

it's to get them out of that predisposition that things have to be perfect before I communicate it.

quite down and we need to reverse the spiral now our predisposition to getting in a downward spiral is affected by

So you thank God.So maybe that's a small component of the psychological predisposition that led to religion.Another one might be the tendency for children to obey and believe their parents.

overwhelmingly. I fudged as little as possible only to make the story work in small details, but there is talk in the book about a 'murder gene' or a 'warrior gene' and thisis a genetic mutation that has been correlated with a predisposition to violence and that is all true. And in fact it has begun to find it's way into the courts. Thescience is good. There was a very interesting case--just to digress a little bit--it involved a guy named

clear that the cause of obesity was a genetic predisposition to fatten. Plus, starches, what he called farinaceous foods, and sugar made everything worse. And for the next 140

So could I infer that everybody has their genetic predisposition, which they start with and their sugar intake regulates them around that? Or how would you describe it?

madagascan primate and apparently lemas have a a predisposition to cataracts who

And they ran it with people who had predispositions against poor people.

beings that make rational decisions that will maximize their efficiency and efficacy in the world. That's kind ofhow our modern society is based means that we have these predispositions to maintaining a status quo to avoidingthings that are uncomfortable or awkward. And so this status quo means that we often perpetuate or assume that

a baseline of our health based on our genetic predispositions all the way to PatientsLikeMe at the other end which lets us build our personal data when we have a disease from Parkinson's

So then how do we use that information to coach?So let's say you come in and you have a brilliant genetic predisposition and you have really high LDL.The coach knows we're going to be able to give some interesting lifestyle recommendations that are actually going to impact that.

But when you finally have symptoms, that's when you're going to show up and present yourself to the health care system.Well, imagine if we understood your genetic predisposition and we understood which omic is unique to you that we should be tracking, if there's something that'srelatively high-risk, and starting to do that at a very low cost.

I'm in this position where people know me and have a predisposition towards me, whether it's good or bad.

Like, was there some sort of genetic predisposition to wheeled vehicles?

Those of us that gain weight are gaining weight because they have a genetic predisposition to do so in an obesogenic environment.

I mean I don't think religion has a direct genetic survival value in the way that sexual lust does.But perhaps another way to put it would be that there are psychological predispositions which under the right cultural circumstancesmanifest themselves as religion.

Angel, thank you very much for your time, your predisposition and for being with us today.

And so migraine is, if that is what your genetic predisposition is, then having chronic inflammation or chronic pain induced by your jaw,

Right? So are you guys thinking more about that field, going more in that-- So right now the message is primarily,optimize wellness. But what's interesting is to look at genetic predisposition both for wellness and for disease.And so we're now launching some clinical trials.

Our co-founder, Dr. Lee Hood, believes that Alzheimer's is probably actually eight to 10 different diseases.And so, if you go in and understand someone's genetic predisposition, well, it could be then the omic that's triggered the disease-- say it's a proteinor a metabolite or a clinical lab or even something in your gut-- if you understood the genetic predisposition, for different individuals then, you'd

And so, if you go in and understand someone's genetic predisposition, well, it could be then the omic that's triggered the disease-- say it's a proteinor a metabolite or a clinical lab or even something in your gut-- if you understood the genetic predisposition, for different individuals then, you'dactually look at different omics to say is the disease triggered?

So we submitted a paper on the first 108 individuals.And what our scientists did is that we came up with a correlation network where we looked at someone's genetic predisposition.And then we found what were the signals to that genetic predisposition to metabolites, proteomics, clinical labs, gut microbiome.

acceptable to wait for other enemy warheads to hit before you launched your warheads-- they have always had a launch on warning predisposition--

So if you're liberal or conservative, about 50% of that belief comes from a genetic predisposition.

So what this translates into is our evolutionary program, our evolutionary predisposition to crave calorie-dense foods.

Male Presenter: Even though you had a predisposition for Japanese culture.Mark: Yes, yes. But not a predisposition for Japanese food.Male Presenter: Yeah. Yeah.

It's hard to say whether the charity actually drives business or whether it like creates a predisposition for, you know, like a customer to be like more receptive to it or not, but,

Alright, so the genotype what you would expect based on my genetic predisposition and what I've been able to produce through training are two very, very different realities.

As you write in your book, we genetically vary in our predispositions to be happy, as we do for all traits.

So first we did whole-genome sequencing and we tried to be really clear.Genes are not your destiny, but it gives us some really interesting insights into predispositions.So that's quadrant one.

So really focus on how you can sort of compensate or undo some of those myths or some of those predispositions