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How to pronounce "nucleases" in English

nucleases is pronounced with standard English phonetics, with primary stress on the “NU” syllable. Hear authentic native speakers pronounce it in 30 clips with synchronized subtitles and timestamps below.

NU·clea·ses

Primary stress: nu

Accent:
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Hear native speakers say nucleases in context across real video clips

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Syllablesnu · clea · ses
Hear it in contextUS
16:05
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Linguistic Pronunciation Masterclass: “nucleases”

Phonetic mechanics, syllable architecture, and conversational cadence

Syllable Architecture & Stress Distribution

Syllable 1Primary Stress

NU

Elevated pitch, sustained vowel length, and full acoustic clarity.

Syllable 2Unstressed

clea

Reduced vowel sound, relaxed jaw, and minimal vocal effort.

Syllable 3Unstressed

ses

Reduced vowel sound, relaxed jaw, and minimal vocal effort.

Primary emphasis falls on the first syllable ("NU"). Raise your pitch and sustain the vowel length on this syllable while relaxing the surrounding syllables.

Common Pronunciation Traps & Learner Mistakes

⚠️ Unstressed Syllable Vowel Reduction (Schwa ⁄ə⁄)

The Trap: Avoid pronouncing every vowel with full acoustic weight. Non-native speakers often over-enunciate unstressed vowels.

How Native Speakers Say It: Only give full vowel clarity to the primary stressed syllable. Relax all unstressed vowels into a neutral, low-energy schwa (⁄ə⁄).

Connected Speech & Natural Conversational Flow

🔗 Consonant-Vowel Linking (Liaison)

When "nucleases" is followed by a word starting with a vowel, glide the final consonant into the opening vowel (e.g. "nucleases is" sounds like "nucleases-iz").

⏱️ Stress-Timed Rhythm

Maintain the stress-timed rhythm of English: compress unstressed syllables rapidly so the beat of "nucleases" aligns naturally with adjacent words.

Authentic Spoken Quotes from Native Video Context

Verified Transcripts
“but also the discovery of new vectors, synthetic vectors, the application of gene editing through nucleases, transposons.”
— StanfordWatch clip
“crispr craze it's a class of nucleases uh that where rna finds its way to dna”
— Harvard UniversityWatch clip
“They are nucleases that our natively present in a lot of different bacteria.”
— MIT OpenCourseWareWatch clip
“Typically, proteins called nucleases trim the broken ends and join them back together.”
— TED-EdWatch clip
“I love nucleases. I see a positive carbocation there.”
— Khan AcademyWatch clip
“While most of the gene editing research you hear about these days uses a tool called CRISPR, this treatment uses a system known as zinc-finger nucleases.”
— SciShowWatch clip
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Practice Speaking “nucleases”

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but also the discovery of new vectors, synthetic vectors, the application of gene editing through nucleases, transposons.

Hear it in context: “nucleases”

30 clips

The English word “nucleases”. Phonologically, it consists of 3 syllables (nu · clea · ses), with primary lexical stress placed on the 1st (initial) syllable (nu). Grammatically, “nucleases” functions as a noun. SayItVid indexes 30 authentic English video clips demonstrating how native speakers articulate “nucleases” in natural connected speech across American (US: 8 sampled), British (UK), and Australian (AUS) accents, including verified broadcasts from Stanford, Harvard University, MIT OpenCourseWare.

Spoken Video Transcripts & Contextual Quotes (5 Verified Clips)

  • 🇺🇸 USStanford
    Clip #1 · @16:05
    “beyond ex vivo autologous gene therapy and stem therapy, but also the discovery of new vectors, synthetic vectors, the application of gene editing through nucleases, transposons. synthetic vectors, the application”
  • 🇺🇸 USHarvard University
    Clip #2 · @3:41
    “therapies ever which is uh sometimes called crispr sometimes called the crispr craze it's a class of nucleases uh that where rna finds its way to dna with protein as a mediator and this can be made extraordinarily specific is is”
  • 🇺🇸 USMIT OpenCourseWare
    Clip #3 · @8:48
    “and these are called restriction endonucleases. They are nucleases that our natively present in a lot of different bacteria. in a lot of different bacteria.”
  • 🇺🇸 USTED-Ed
    Clip #4 · @3:27
    “the cell will try to repair it. Typically, proteins called nucleases trim the broken ends and join them back together. trim the broken ends and join them back together.”
  • 🇺🇸 USKhan Academy
    Clip #5 · @2:21
    “still like giving away electrons to nucleuses. I love nucleases. I see a positive carbocation there. I see a positive carbocation there.”

Definition & Meaning: “nucleases”

NOUN
  • The positively charged central core of an atom, consisting of protons and neutrons.

Example Sentences (3)

  • “The nucleus of an atom contains most of its mass.”
  • “but also the discovery of new vectors, synthetic vectors, the application of gene editing through nucleases, transposons.”
  • “crispr craze it's a class of nucleases uh that where rna finds its way to dna”

Common Phrases & Collocations

finger nucleaseslove nucleasesnucleases trim

Pronounce: “nucleases”

Syllables:
nu · clea · ses
Primary stress:
nu
Hear it in context
nucleases

Words that Sound Identical (Homophones)

Unique Sound
Explore 800+ homophone pairs

"nucleases" has no true homophones in standard English — there are no other words with identical pronunciation. Unlike sound-alike pairs like there / their or peace / piece, "nucleases" has a completely distinct phonetic identity.

Frequently asked questions about nucleases

How many syllables are in “nucleases”?

“nucleases” has 3 syllables: nu · clea · ses.

Where is the stress in “nucleases”?

The primary stress in “nucleases” is on “NU”. Listen for that stressed syllable in the clips above.

What does “nucleases” mean?

The positively charged central core of an atom, consisting of protons and neutrons.

How can I hear “nucleases” used in real sentences?

This page has 30 real-world video examples of “nucleases” with synchronized subtitles. Use Previous / Next (or ← / → keys) to hear each one at the exact moment it is spoken.

What is the most common pronunciation mistake when saying “nucleases”?

Avoid pronouncing every vowel with full acoustic weight. Non-native speakers often over-enunciate unstressed vowels. Only give full vowel clarity to the primary stressed syllable. Relax all unstressed vowels into a neutral, low-energy schwa (⁄ə⁄).