So the reality is that 90% or more of deaths from breast cancer-- again, half a million in the world every year-- are caused by metastasis . That's when the disease spreads outside of the breast to other organs.
How do we stop women and men from getting breast cancer to begin with? And the second is this idea of metastasis and the spread of breast cancer outside the breast. We know if it's in your breast and doesn't go anywhere, you'll live.
We develop DNA dates that will go and hybridize with the parts of the genome where the cancer mutations are most likely to be found. All of these are actually metastasis from her cancer.
Because as I said, every breast cancer is different. So I think that the ability to treat metastasis , it has been a growing effort in the breast cancer community. Most clinical trials that are started are done in patients with metastatic disease.
What targeted therapy should we use? the key to what is the transformative therapy or therapies that could prevent metastasis .
What targeted therapy should we use? The other area, as Fran, mentioned is preventing metastasis .
What targeted therapy should we use? Some want to focus just on, how do we treat metastasis ?
It starts in the bones-- that's the most common site-- but then spreads to other organs and, unfortunately, is incurable. The trick though, is that it's not so easy as catching the tumor early and thereby preventing metastasis , getting it before it metastasizes. Those 20% to 30% of breast cancers that eventually come back as metastatic disease do so probably before they're ever diagnosed, probably when
But then, ultimately, there's resistance, and it doesn't extend life as long as we would like. So really, to prevent death from breast cancer, we have to figure out how to treat metastasis and how to prevent it from ever happening in the first place or, as Fran mentioned, of course, prevent breast cancer from arising at all, even in the breast.
What targeted therapy should we use? So in the Artemis Project, one example is we identified the questions related to how to prevent metastasis .
And my response, thanks to my wife, was there's only one Warren Buffett. That FP division had absorbed enormous risks and became, really, a cancer that threatened to metastasise across the company until the great surgeons
So I think that the ability to treat metastasis , it has been a growing effort in the breast cancer community. Most clinical trials that are started are done in patients with metastatic disease. But we still need to make a lot more progress.
The trick though, is that it's not so easy as catching the tumor early and thereby preventing metastasis , getting it before it metastasizes. Those 20% to 30% of breast cancers that eventually come back as metastatic disease do so probably before they're ever diagnosed, probably when the tumor is developing.