The image we have about strength and like achieving things and getting stuff done, I think is still very old-fashioned. And in a way, the metabolism more efficient and resourceful actually. And that is quite a nice effect because having less sex hormones, having less immune cells,
The glaciers grew into ice sheets. And that helped drive the temperature of the entire world to be much cooler. Now, this was a long-term trend then that continued to happen for many tens of millions metabolism , of course, their ability to fly. These are very unique things. And there's really nothing else today that looks like a bird. But if you look into the fossil record, you can actually see that
like smoking be cancer causing? metabolism , right? From the food to your mitochondria, then that whole circuit becomes more resistive. And then if you're an
So I'm now obviously restricting myself to biology, to living organisms. Metabolism is the word that biologists use to encompass all of the stuff that the body does from one day to the next to keep us going,keep us alive. And metabolism creates damage, and damage accumulates through our lives, even starting before we're born.
So the idea was, well, if we study this really, really, really hard, then maybe we'll eventually figure out enough about how metabolism generates damage that we will be able to slow it down.We'll be able to develop therapies that will somehow clean up our metabolism so that it generates damage more slowly, and thereby, we postpone
And this is why. Metabolism is rather complicated.Since I'm speaking to a bunch of coders here, I can immediately just say, well, OK, this is obviously the ultimate nightmare
it particularly well. If we're not proposing to do anything about the rate at which damage is created, it's fine that we have such a pitiful understanding of what metabolism actually does and how damage is created.Similarly, if we're not proposing to let damage reach a level of abundance that causes pathologies to occur, it's fine that we don't have much understanding
your thyroid is literally the metabolic Center of your entire body okay so it's like the center control center of your metabolism so cortisol is important it's just if it's produced at the wrong time and it and in in the wrong amount iswhen it could become a problem all right so here's why this is an issue sleep deprivation immediately has an elevated
So a half cup serving of lentils provides 45% of recommended daily folate, which is necessary for the production of red blood cells and protein metabolism . You've probably heard it's important for women of childbearing age because of its role in the developing embryo.Also a cup of lentils has potassium comparable to a banana-- potassium important for electrolyte and fluid balance as well as muscle and cardiac function.
If you look at the bottom of this diagram, what I'm saying is what I told you already. Metabolism causes damage, causes pathology.In other words, the network of processes that keep us alive from one day to the next, which is what biologists call metabolism ,
But worse than that, the gerontology approach suffers a problem that is rather analogous to this problem, namely-- there we go-- this problem. Metabolism is rather complicated.This is a simplified diagram of a small subset of what we know about how metabolism really works, about how the body works.
about super immunity or how to build our resistance, to an aromatic herb farm that teaches us, actually, how plants have special messages for our metabolism in our body.But I'm going to tell you one story today.
can go on to be diabetes because that fat in muscle Alters the glucose metabolism just the number of cases of type 2 diabetes if you look go back adecade it was four 4.8 cases per thousand in the United States in the
weight because our bodies think oh we're starving better slow down the metabolism and there there are some studies that I you know put out here incomic form just to remind us that it is hard but it's not
So in 1838, French scientists proposed a different scaling law. Since metabolism generates heat and that heat is radiated through the surface, metabolic rate or B, should scale in proportion to the surface area, A, instead. This became known as the surface law.
like smoking be cancer causing? mitochondrial metabolism has become a major promising frontier in developing new cancer therapies.
I was like, great, I'm happy for you. Fast metabolism . Yeah, maybe fast metabolism .
But when I was pregnant, I had no interest in those things. Your metabolism determines how efficiently you use the calories that come in.
The other one is, I feel like-- so you say a lot of young people especially, I think what you mean is that a lot of people, their their metabolism is much more forgiving than, for example, later in time. Right. What is that is accumulating over this period that sort of, you know, lifestyle, that could be prevented,
Let's sit here and have a baseline, hypotheticals. Male metabolisms , male hormone profiles-- they're built for that.
The cancer community used to think that dominant driver for cancer was genetic mutations, but there's an emerging perspective that changes in metabolism , changes in the way electrons flow through through this energetic circuitry, through the mitochondria, can actually drive the instance of a of a new cancer cell. And
And if you rewire metabolism , that will tend to rewire gene activity as well.
And that's rewiring metabolism as we get older.
got a metabolism . How does information emerge from that?
Also key for our metabolism and, of course, digesting our food, which is what everyone thought they did, initially.
to boost metabolism . And he even shows us how taking medications at a certain time can combat certain conditions.
So that your metabolism can actually do all the repairing work.
Everyone's metabolism is different.
And what affects my metabolism ?
And of course, what that means is that we can leave metabolism alone. We can let metabolism generate damage at the natural rate, and still, it won't reach the level of abundance that causes pathologies to emerge.
killed your metabolism . And he proved the opposite.
It actually increases your metabolism .
Because that's what metabolism is.
I feel like you hear a lot of different things about, eat multiple small meals a day. Keep your metabolism going, versus I eat one meal a day. What are your thoughts on that and constantly fueling your metabolism through lots of snacks?
Fat helps regulate your metabolism .
an even metabolism . And that's great in principle, but only about 7% of people who snack eat snacks instead of meals.
But when I was pregnant, I had no interest in those things. And then metabolism -- and, of course, your metabolism is genetically based.
But when I was pregnant, I had no interest in those things. So that's metabolism . After losing weight, your hormone levels change.
She also had a metabolism that was like the Energizer bunny.
This is a yeast metabolism .
the inflows of the metabolism that it needs to survive.
We've had saturated fat in our diet for millions of years from bone marrow and brains. So our metabolism is well-adapted to metabolizing, to harnessing it as an energy source. So you see issues like that where this bottom-up, open source community is moving much faster than the conventional health authorities.
And whatever your metabolism is-- So I don't suggest that people do drugs to
Others have different metabolism .
flask and your metabolism is the Bunsen burner underneath.
If you look closely, you can also see some significant drops like this 1918 dip from the Spanish flu pandemic or over here, what appears to be And in recent studies of bird metabolism , you also find a slope that appears closer to two-thirds than three-quarters.
But then in anticipation of increased metabolism , increased muscle efficiency, core body temperature rises and is high throughout the day.
And the idea of ramping up that metabolism either first thing in the morning or at the end of the day I think
And so let's look at metabolism .
But it's also because of my metabolism .