melanoma .
Melanoma , Ted answered.
melanoma which the dog is detected so now there is basically this is research
Melanoma , the lethal skin cancer everybody is afraid of, always always develops in the places that have not been exposed to the sun.
melanoma um and here in this particular subset uh the ages are shifted a little bit to the right so these are older
melanoma so if that's the case in melanoma what might be the biological uh features that would distinguish a young
melanoma so again when we start to take a look at these big epidemiologic Trends and put data from thousands and
melanoma specifically how do we move from biology like that to treatment so I mentioned before one of
melanoma we based hos 2 with this vague idea that maybe the immune system could be active in treating cancers like
melanoma so how might it work well it's right here um you can see at the top we
melanoma cell and essentially cause cancer all of these little uh uh classes
melanoma um and each of the lines is an individual patient so the zero of the dash line would be if you took the
melanoma leading to a difference in treatment how does that relate to young people in age Well turns out if you look
melanoma uh risk in a good way um just published last week vitamin D
with melanoma .
of melanoma and other things.
in melanoma -- in this case, , which is a selective inhibitor of RAF-- you can see these type of incredible effects.
person melanoma from an older person melanoma and in this graph this is a graph of the incidence of melanoma based
and melanoma you'll actually find in the first page AG a whole bunch of controversy all right um it is well
invasive melanomas so this is the kind of data that we stand by to say that sunscreen uh not only sort of
treatment and what is melanoma ?
develops a second melanoma , this wouldn't work on that second melanoma .
Center for Melanoma at Mass General Bighgam Cancer Institute.
He had had a melanoma underneath his arm, and they took tissue from the damaged part and re-injected.
Same was true of melanoma cells, there was a nice pattern of gene expression in these cells.
This looks like a melanoma , not a breast cancer at all.
talking about melanoma um but before I do that let me start where Shannon left
adult cancer and where melanoma fits in uh this is uh uh not to scale but is
always cutaneous uh melanoma and and it's predominantly in Caucasians U but not exclusively in
in uh melanoma cases in the United States and US females and until data presented last
approved drugs for melanoma uh were developed
thousands of melanoma patients together we start to see what may be different about young adults uh with cancer so in cancers generally and in
for metastatic melanoma are still alive so it can be a very valuable therapy it's a toxic therapy as well uh but this
Sun's bad for melanoma yet vitamin D that can come from sun exposure might be good for cancer and even good
specifically for melanoma and in fact there were studies published and often
decrease in mortality from melanoma so it's not actually as as straightforward as as that how about sunscreen so sunscreen is
at high risk for melanoma right people who have freckles and white skin like me know that they can't survive a sunburn
much less their melanoma risk without wearing sunscreen um and so it's hard to tease apart the use of sunscreen in an
This is someone with metastatic melanoma .
They didn't work in metastatic melanoma .
fits exactly with the concepts of melanoma and with young adult cancer which is a a big uh mission in the
ovarian cancer in women thyroid cancer and melanoma
that we're learning about melanoma now this is a cartoon of a melanoma cell across the top is a cell membrane and
left Peak it may be that younger melanoma has unique biology that we can Target all right um I am a physician as
knows that Sons associated with melanoma that you wear sunscreen stay out of the sun etc etc uh but we've been saying
it actually reduced their incidence of melanoma um so that's confusing because
with a decrease risk of death from melanoma both sunburns uh High
And that was about 50% of melanomas , but also scattered throughout other tumor types.
It is so easy to prevent melanomas , which kills tens of thousands of Americans every year.
So melanoma is a type of aggressive skin cancer caused by