But what are these manganese complexes? Manganese is a transitional model that is able to combine with different molecules, especially small metabolites like nucleosides, amino acids, and peptides, and aryl phosphates.
a big following among lesbian fans because two of the heroins in it are a couple she's also a fan of Rosa Versa a historical manga certain pre pre-revolutionary France whose heroine is a crossdresser who commands the palace guards and is admired by both men and women her blogs like to talk about anime and manga that feature lesbian
The red button? Well, for those of you who don't know, there's a little red button with a bonus panel on each comic. And Manga Studio is the software I use.
If the trauma or adversity involved another person who was untrustworthy that we trusted, it calls into question our ability to evaluate people and decide who into manga . Into manga .
The atoms inside the cathode in that battery just move everywhere. The manganese goes over here. The cobalt goes over there.
That's how our album packaging was. For the manga -themed one, called "Happy Ending,” it was a comic book. Every page is a comic cover. Because the songs are based on comic characters or book titles.
Or hate, for example, seems pretty bad. Were there particular manga titles that you felt really inspired you and you found yourself weaving in, or somehow the elements would
You can easily get hooked when you go In line with this We also have a cyber café, or an internet café It is a Manga café This is also something we have So Let's get into today's topic I'd like to present today's topic I, Matsumura, read "Ten Things I Know to be True" I was strongly moved, and thought about the affinity it had on my business
And it'-- I think there's lots of different spaces to do that. She uses Manga Studio, and then prints it out, and then inks the printout.
and free content, and freely available amateur content. And the downside for them is unlike, let's say the music business or the movie business, they don't have sort of a live component compared to the Manga in Japan where technology is seen as evil. So is, like, is war the contrast
And whe- whether he's flashing peace or victory, I cannot say. Because it's 66, hopefully it's peace. So that's Bat-Manga and um there's you know, there's more about that on the web and um you'll see when when we get the book.
And some of those examples I show here from some of our previous work, the stars that you see on the interior of each one of those manganese oxide stars is a tiny microorganism. And it causes the precipitation of that manganese oxide as a byproduct of using other oxidation states of manganese minerals to make its living.
In the case of resistant cells, they accumulate a lot of manganese, manganese-to-iron ratio. And these manganese forms complexes with small peptides and nucleosides inside the cell. And then it ends up quenching and scavenging the effects of these free radicals on the cells.
And the cells remain alive. But what are these manganese complexes? Manganese is a transitional model that is able to combine with different molecules, especially small metabolites like nucleosides, amino acids,
So this motivated us to go through extreme places on Earth, actually deserts, enriched in manganese, so combining the dessication factor and the manganese availability. So I've been through the Sonoran Desert in Arizona in a collaboration with a company called American Manganese.
And after a period of incubation, we isolated the colonies that grew after the largest doses and performed survival curves, characterized the extracellular and intracellular manganese-to-iron ratio through ICPMS and did some optical and electro-microscopy studies. So we were surprised to see high diversity on samples coming from the Atacama Desert compared to samples from the manganese mine in Arizona
So the cells needs need to have molecular mechanisms to uptake manganese from the environment. So the availability of manganese in the environment does not determine radiation resistance. But those that can accumulate high manganese-to-iron ratio, they will have a better chance to be radiation resistant.
Clay: Yeah, yes to the first, no to the second. So, one of the great, one of the great about the Mangalore story is that she used Facebook to gather the group, but then she immediately moved to a very high cost signal.
Well, I used to work as a management consultant. She read a bunch of manga when she moved to the UK on Shakespeare and classic English literature, like "Pride and Prejudice," so that in dinner parties
And Hindustan Unilever was facing the heat of competition. including a part of the Mangalyaan project which went to Mars.
of those manganese oxide stars is a tiny microorganism. And it causes the precipitation of that manganese oxide as a byproduct of using other oxidation states of manganese minerals to make its living. And it produces these characteristic things.
We have Ben Yu and Simar Mangat over here.
So the availability of manganese in the environment does not determine radiation resistance. But those that can accumulate high manganese-to-iron ratio, they will have a better chance to be radiation resistant. So then we did survival curves with the most radiation resistant ones.
I mean, why can't you just use lithium ion that we have right now? Try to put in more manganese.
Have you ever worked with Mangalitsa before?
It also captured that era— because it had lots of game and character names. Later I made an album called "Happy Ending," which used manga as a theme. It may seem personal, but it also reflected that time, that era— what was popular then.
Because of the popularity of smartphones, I believe that work will reduce down to half This is the Gran Cyber Café It looks very cool This is what a manga café looks like these days It looks very good If you do not work on gathering information, you will not be able to keep up Gather information, and input, input, input I think collecting various information is the only way Because you have these drawers filled with information, when different things come your way
palace guards and is admired by both men and women her blogs like to talk about anime and manga that feature lesbian characters she's huge on Yuri which is manga about love stories between girls when we looked at her Facebook and and her Instagram accounts the photos were of her with a lot of female friends and several of them were lesbians and
think it's actually really really good drawing and really really good cartooning. Um he was the he was a a manga prodigy. He started drawing professionally in the '50s at age 13.
And the founder, Ben Mangan, one day woke up and he thought, we're getting all this recognition, but, really, there are an estimated 50 to 70 million
being sensitive organisms, they have a low ratio between manganese and iron intracellularly. And the resistant ones has have high intraceullar manganese-to-iron ratio. And this suggested actually that maybe proteins also play-- the damage to proteins is also critical for recovery
complexes in human cells. We can see here human cells treated with manganese pyrophosphate is significantly more resistant than the known treated control. So this is a very interesting line of research that could benefit future astronauts going to Mars.
And the question we have is whether there are other biological models available in nature that we don't know yet. So maybe other organisms could accumulate higher levels of manganese, may have more efficient DNA repair, and may produce antioxidant secondary metabolites that are more higher level of these metabolites.
So we now have this microbiological culture collection with radiation-resistant organisms with different levels of radiation resistance. And then we looked into the extracellular and intracellular manganese ratio and compared to the survival of these organisms. So this graph shows that the extracellular manganese-to-iron ratio, the availability of these metals does not determine the survival of organisms
And this happens because the inputs, the uptake of manganese, occurs as an active mechanism. So the cells needs need to have molecular mechanisms to uptake manganese from the environment. So the availability of manganese in the environment does not determine radiation resistance.
There are other things being produced. And then they started to see that organisms that accumulate high manganese had these trend of being resistant to radiation.
One, Mangahigh, where you learn maths by playing games, and which is a great idea that the only challenge-- the real
Well, a lot of it is public pressure as well. I remember when I first told a friend of mine reading a manga comic called "Lone Wolf and Cub." And I was waiting for her in a restaurant. And she said, "You can't read comics forever, can you?" And it was a little bit offensive to me because she just genuinely looked down on them.
but it all adds up she's a big fan of Science Fiction and Fantasy Books and shows that featured and shows that featured prominent gay and lesbian characters she's a big fan of the Salem Moon Manga and Anime and that Series has a big following among lesbian fans because two of the heroins in it are a couple she's also a fan of Rosa Versa a
If the trauma or adversity involved another person who was untrustworthy that we trusted, it calls into question our ability to evaluate people and decide who Because of her costume, it looks manga -esque.
If the trauma or adversity involved another person who was untrustworthy that we trusted, it calls into question our ability to evaluate people and decide who Because of her costume, it looks manga -esque.
possible. But um I just want to do a really quick introduction for Chip Kidd. Um he'll be talking today about a uh the new book Bat Manga , The Secret History of Batman in Japan, and he'll also be giving a presentation about design and other projects he's working on. Um you probably know who he is. He's a designer, a novelist, and a huge Batman
But there was sometimes, like in Mangalore once on the street, I was very surprised to find a chess fan.
So one of these factors, maybe the most important physiological factor that factor that contributes for radiation resistance, is the accumulation of manganese. Actually, it's the ratio between manganese intracellularly. This was demonstrated almost 12 years ago by the group of Michael Daly.
because they were not living up to our ideals of Hindu womanhood. They were not being sufficiently chaste. They were not being sufficiently private and our next attack is going to be on Valentine's Day. If you're a woman in Mangalore and we catch you out of doors with a male who is not your blood relative, we will attack you again." Right? So, this puts the women of Mangalore into a classic collective action problem. Each woman, faced with a question of what do to on Valentine's Day, can say quite reasonably,
Day. If you're a woman in Mangalore and we catch you out of doors with a male who is not your blood relative, we will attack you again." Right? So, this puts the women of Mangalore into a classic collective action problem. Each woman, faced with a question of what do to on Valentine's Day, can say quite reasonably, "I'm staying home." But, of course, by doing that, collectively they will be capitulated to, to seeing his demands. Or, each woman could say, "Perhaps there will be strength
So, against, against this threat, by Pramod Muthalik, who's the, who's the, the leader of Sri Ram Sena, steps up a woman who offers a third option to this collective option dilemma, Nisha Susan, who is a Mangalore resident and Susan proposes a way to solve the collective action problem collectively, rather than having the solution have to be worked out by, by each of the individuals. And so she founds my favorite Facebook group, the Collection
MIGUEL BOSÉ: Sí. Porque en aquella época estabas obsesionado con el manga .
just thought that would be too much was all out to do it yeah that is all the two on the nose um and an assortment of anime she was a huge Sailor Moon fan both the manga and remastered DVDs occupied a place on her shelf that was practically an alar how do you recognize all that stuff anyway
historical manga certain pre pre-revolutionary France whose heroine is a crossdresser who commands the palace guards and is admired by both men and women her blogs like to talk about anime and manga that feature lesbian characters she's huge on Yuri which is manga about love stories between girls when we looked at her Facebook and and