How to pronounce “telome” in English

Let's talk about telomeres now.

And as our telomeres get shorter, our lives get shorter, and the risk of premature death from heart disease, diabetes, most forms of cancer,

You can worry about telomeres. Lots of people talk about telomeres, I think partly because they like the word.

She was doing early work on telomeres, actually studying pond scum, because it was cheap and readily available, and

this cellular replication and control telomeres.

Talk to us about what are telomeres, first of all, for those in the YouTube land who may not know yet?

So for example, your telomeres will shrink over time.

But one thing that was really striking is that his telomeres actually got longer in space, so you can see here.

Well, telomeres are-- the analogy that Liz Blackburn often gives is they're like plastic tips on the ends of your shoelace to keep your shoelace from unraveling.

I don't know if you've heard of telomeres.

Talk to us-- you've been interacting with one of the founders of the whole telomeric medicine-- Liz Blackburn.

And as we get older, our telomeres tend to get shorter.

It was how the women were reacting to it that determined its effect on their telomeres.

It's still the only control study showing that any intervention can actually make your telomeres longer.

You know, the ends of the DNA -- telomeres. If we learn how to manage that relationship -- that's a mechanical definition of aging is, You can lose that material, you're rolling

Here, too, lead to higher telomeres for the twins that were on Mount Everest, as well as now 11 other astronauts.

There were lots of advances being made, including the discovery of telomeres, which are repeating segments at the ends of chromosomes that essentially protect

And what findings did you show in terms of the impact of these kind of changes on telomeres themselves?

increased by 30%. And after five years, the telomeres got 10% longer, whereas they got shorter in the control group.

and dies. But stem cells express an enzyme called telomerase, which will extend the telomeres on the cells.

It sounds kind of sexy and science-y. The problem with telomeres is that actually in some species the telomeres get longer as they get older.

And so far we've seen this seems to be a very consistent feature of spaceflight, is that your telomeres will get longer,

So we've declared as a field, as you said, that there are eight or nine hallmarks of aging, and some of them are telomere shortening,

Then in 2009, she, Blackburn, and a third scientist who had worked on the early work of telomeres won the Nobel Prize in Physiology and Medicine.

We've found it to reverse heart disease, diabetes, prostate cancer, change your gene expression, lengthen your telomeres.

And so across 500 genes, both in terms of up-regulating good ones and down-regulating bad ones-- we'll get to telomeres in a second,

with Alzheimer's or kids with autism-- the more stress they felt and the longer they felt that way, the shorter their telomeres were.

And so I thought, well, OK, if bad things make your genes shorter-- I mean, your telomeres shorter-- maybe good things make them longer.

So we did a study together, and we found that after just three months, the telomerase-- which we published in "The Lancet Oncology"--

Honestly. If the letter needed shipping to the Shining Empire, or west across the sea to Alt Coulumb, or even north to Telomere, the demon

Some of you are probably aware of it, but one simple, simple, simple idea is the telomeres.

So in this case, we looked at genetic changes, epigenetic changes, RNA changes, protein changes, chromatin and antibody titers, B cell, T cells, telomeres,