How to pronounce“mitochondrial”in English

mitochondrial dysfunction, loss of stem cells, senescent cells.

from mitochondrial dysfunction through to senescent cells, senescent cells being the ultimate expression of a scratched CD.

The mitochondrial genome is inherited as one unit.

which is considered a mitochondrial disorder, a lack of energy.

But Neanderthal mitochondrial DNA go much further back to a common ancestor, half a million years or so.

And men have mitochondrial DNA, it just comes from their mothers.

levels of-of mitochondrial function, and all sorts of things that are novel biomarkers that don't specifically look for a disease but look for patterns in the data; look for

So you have what are called mitochondrial adaptations that are better.

Providing evidence that the intermittent fasting bolsters mitochondrial resilience.

And it just turns out that mitochondrial DNA accumulates mutations far far faster than the nuclear DNA.

So they look quite different in their mitochondrial genome.

I was biased after the mitochondrial genome was saying that there had been no contribution.

Why didn't we find any mitochondrial contribution when we now see it in the nuclear genome?

What does that mean, mitochondrial metabolic disease?

and providing evidence that the intermittent fasting bolsters mitochondrial resilience and actually increases

The ones that are inside-- the first one is mitochondrial mutation.

There are no humans today that run around with a Neanderthal mitochondrial genome.

So that was then the picture for this mitochondrial genome.

my main contributions have been more on the particular area of mitochondrial mutations and their accumulation and the ways in which they do damage and those

DNA is a DNA test that literally uh looks at the mitochondrial uh

intimate contacts between some of the other membranes, mitochondrial associated membranes we see.

And now we're using energy so uh this organelle signals to the nucleus called mitochondrial stress response

My PhD was in mitochondrial biology of aging.

You mentioned the mutation rate in nuclear DNA is much lower than mitochondrial, and that makes sense.

nuclei that comes only from the mother, the mitochondrial genome because there are many, many copies of it per cell, so a bigger

What effect does the mitochondrial DNA have on this whole process?

And then we have a series of other brand new technologies like mitochondrial replacement therapy where you're taking the egg from one woman, you're removing the mitochondria from

that egg and putting in the mitochondria from another egg to deal with mitochondrial disease and here there's an idea that there's actually three genetic parents: the genetic father

who provides the sperm, there's the mitochondrial donor and there's the woman who donates the rest of the egg.

The new technologies we've been talking about, mitochondrial replacement therapy, also CRISPR/Cas9 gene editing, which is a technology we're going in the lab.

Bob , who is an amazing mitochondrial researcher in California, who talks about the cell danger

So this, what I've shown you down here-- this is the mitochondrial phylogeny of these animals-- the mitochondrial gene tree.

So with the technology at the time, we retrieved a part of that mitochondrial genome with great effort, short little pieces, many, many times over,

And what we saw was what was already known, that all mitochondrial DNA of everybody living today go back 100,000, 200,000 years,

So in reality there's three genetic parents, even though the mitochondrial donor is only giving a very small part of genetic material in the DNA.

DNA from the Y chromosome and you can amplify that up with the PCR and then there's another technique called mitochondrial DNA testing mitochondrial

mitochondria within a cell it's sort of the PowerHouse of a cell and that's maternally inherited so your mitochondrial DNA is the same as uh your

And so he wanted to level the playing field for these children with cancer, sickle cell, HIV, rare diseases, metabolic, mitochondrial disease.

He clearly showed that cancer was a mitochondrial metabolic disease.

But I guarantee you, if you do less of the stuff that makes you weak with your genetics, your biome, your mitochondrial DNA, you're going to like it.

We were then able to do DNA testing many years later on the shafts of those hair, something called mitochondrial DNA testing, and able to demonstrate

So the question is OK, hang on, we've got mitochondrial mutations here.

looking for the things that were consistently there, and then reconstructed such a phylogenetic tree for the mitochondrial DNA then, this tiny part of the genome.

So if it was particularly Neanderthal men who contributed to the modern human gene pool, it would also bias against mitochondrial DNA.

And so technically, clones aren't quite perfect copies of their genetic donors, because they have the mitochondrial DNA from their egg donors.

So I tell people, look, if you're over 40, one milligram a day might be a good idea, because it enhances mitochondrial function, and because we don't want to get Alzheimer's

So those are four technologies: artificial insemination, in vitro fertilization, surrogacy and mitochondrial replacement therapy.