endothelop protective mechanisms. They protect the blood vessels. They make them healthier. And so when your blood vessels are healthier, you get better metabolic health. So you get less diabetes, less high blood pressure, less high cholesterol. And these all of these things together improve erectilefunction. So I think making sure that you meet the criteria for fiber, which is 38 grams
not eating after about 12 hours. And by the way, this is all relative because it depends on the kind of foods you eat and metabolic switch because your body still needs energy, but there's no nothing, no glucose around, right? So, you start to switch to, you know, your fatty acids
Let's sit here and have a baseline, hypotheticals. metabolic pathway. Does that make sense?
Any cat can pick up a kitten and run for it. Metabolic syndrome is where your body is no longer processing the sugars anymore.
And we can see that evolution would have optimized us for a certain type of environment where there are trade-offs between, maybe, metabolic consumption of the brain and the amount of mental energy you have.And in the environment of evolutionary adaptiveness, the optimum point for that trade-off is at one place, and now we want to move that.
and the intestine or the kidney, muscle, and brain. Eighty percent of the calories, or 96 calories, are gonna hit the liver, four times the substrate as with glucose. metabolic syndrome right there. Now, the other thing that fructose does. It tells your brain
What about sleep deprivation? Night shift workers, university students cramming for a midterm, then all of a sudden the healthy brain becomes a metabolically stressed brain. And most people fall into the stressed environment, and that's where creatine comes to the rescue. And we'll talk about how much, but the more stressed it is, the higher the dose seems to come into play.
scan um uh patients are administered a glucose that's labeled so you can see it on a scan and because tumors are metabolically active they take up glucose so you see tumors you also see the brain and the heart so the Baseline scan on the left you see a whole bunch of black dots that aren't supposed to be there those are all melanoma tumors on the right on day 15 that's after only
have little tiny cognitive light cones. What are their goals? Well, they're trying to manage pH, metabolic state, some other things. There are some goals in transcriptional space, some goals in metabolic space, some goals in physiological state space, but they're generally very tiny goals. One thing evolution did was to provide a kind of cognitive glue, which we can also talk about, that ties them together into a multicellular system.
Feel pretty good, feel okay. Now, I just want to get the best possible out of my life. So, this could be energy. It could be metabolic . It could be cognitive function. Why I can accomplish that and our our folks I work with can is because I'm after the physiology.
The brain was recently-- this is just in the last 10 years, this has been discovered, has its own system for getting rid of metabolic waste. And your brain is doing a million processes every second. So there's a lot of metabolic waste, and a lot of dead cells, and a lot of stuff to get cleaned up.
So this is a study that I did showing that at similar levels of body mass index, there is higher risk of something called metabolic syndrome, which is pre-diabetes. It's a combination of triglycerides, low HDL, which is the good cholesterol; high glucose, obesity, as well as
Let's just arbitrarily say that Gwen had cake every single day. Lower metabolic health equals more fat burn-- or more fat gain.
Let's just arbitrarily say that Gwen had cake every single day. into metabolic adaptations. Make sense?
Look what underlies male infertility. There's very little difference between this and erections. The metabolic syndrome group is up there and it's Building 41 here. You have heart disease, testosterone, stress, sleep, all of it is all part of it and that's all part of the personal history. That's really important. So your infertility could be due to stress.
Let's sit here and have a baseline, hypotheticals. Assuming metabolically adapted, no, that's not going to work because carbohydrates have the most impact on the metabolism, right?
But then in 1932, Swiss biologist, Max Kleiber, decided to put it to the test. He took the metabolic rates of different animals from a small dove at 150 grams to a large steer at 680,000 grams, and then he plotted them against their mass on a log log plot.
as its length squared, but it's length cubed. And since the metabolic rate hinges on how fast resources can be exchanged across the surface area, well, it must also scale like length cubed. But remember, West, Brown and Enquist wanted to explain Kleiber's Law.
Well, remember that metabolism is all about how nutrients get distributed around the body. So most biologists agree metabolic rate and blood flow rate are directly proportional to one another. So heart rate should scale as metabolic rate over mass.
And in the metabolic networks in our cells, you have a few molecules, like ATP, that govern hundreds of chemical reactions.
having wide-ranging metabolic effects, it had an endocrine effect. It was designed to shut down the production of testosterone for prostate cancer
What do you think your body is actually doing in this area? It's downregulating its metabolic response. Why? Because it need survival.
Let's just arbitrarily say that Gwen had cake every single day. The rate of metabolic adaptation is going to happen slower.
and resulting metabolic syndrome symptoms, essentially,
Most of the metabolic processes that make you functional have peaked by age 30.
But you have many metabolic processes which start their failures here.
So most metabolic processes fail here.
We didn't have metabolic syndrome.
Your elevated metabolic rate is not as great from lower intensity exercise.
It's called metabolic rate, namely how much food you need to eat per day to stay alive.
"Is it possible to do irreparable damage to the metabolism or is this a wives' tale?" For that person, I'm going to categorize that as metabolic adaptation. I'll explain that and that should answer your question.
And then his metabolic rate, as we would say today, went up.
have different metabolic patterns than people of European origin.
Africans have different metabolic patterns for reasons we simply don't understand from us.
It's metabolic , heart disease, and schizophrenia two generations later, even though everybody in between, including the original grandparents, had enough food.
You increase your metabolic rate.
intake and metabolic syndrome, and we know about the link between metabolic syndrome and diabetes.
and the intestine or the kidney, muscle, and brain. Eighty percent of the calories, or 96 calories, are gonna hit the liver, four times the substrate as with glucose. That's what metabolic syndrome is. And alcohol does it. Just ask anybody who drinks beer.
and the intestine or the kidney, muscle, and brain. Eighty percent of the calories, or 96 calories, are gonna hit the liver, four times the substrate as with glucose. That's metabolic disease, and its' fast. So here's chronic ethanol exposure. And here's chronic fructose exposure. Eight out of twelve because they're the same. Because after all,
that are known as metabolic diseases, which include fatty liver disease, atherosclerosis, hypertension, stroke, cancer, asthma, sleep apnea, osteoarthritis, neural degeneration.
doesn't happen with visceral fat. What happens is it just keeps going, keeps going, keeps going. What happens is when your visceral fat is metabolically active like that, it is basically making it where insulin can't work its job. And so what happens is that glucose can't go
that might work metabolically?
to conduct metabolically heated aunt air from near the center of
But it turns out that the speed at which an animal can process chemical compounds doesn't depend directly on its mass. It depends more on its metabolic rate. That is the number of calories it uses in a given amount of time.
But remember, West, Brown and Enquist wanted to explain Kleiber's Law. So they needed to know how metabolic rate scales with mass. Since every cell needs to be served by the network, this means that the volume around the network should be proportional to the animal's mass.
So most biologists agree metabolic rate and blood flow rate are directly proportional to one another. So heart rate should scale as metabolic rate over mass. Swapping in the scaling law Kleiber had found, that gives us M to the minus one quarter, meaning bigger animals should have slower
If you look closely, you can also see some significant drops like this 1918 dip from the Spanish flu pandemic or over here, what appears to be - This is a graph of metabolic rate as a function of mass based on a study that looked at 391 species of mammals,
If you look closely, you can also see some significant drops like this 1918 dip from the Spanish flu pandemic or over here, what appears to be The bigger problem is that measuring metabolic rates is difficult.
And that's the continuum of metabolic diseases that spans the gamut from insulin resistance to fatty liver disease to type 2 diabetes.
like the immune system or metabolic pathways, and each person understands only a tiny bit, part of it, specializes,