How to pronounce “kinase” in English

tyrosine kinase-- putting phosphate onto tyrosine residuee-- allowed you to begin to think about, could you develop a specific therapy

This kinase inhibitor would prevent this DNA repair from happening in the cancer cells selectively, and that would thus enhance the effects of the chemotherapy.

And I looked at-- I was working on kinase at the time and thought, here's a disease I know is caused by kinase.

And we know that it functions as an activated intracellular kinase.

and they sequenced a common pathway that's activated in cancer called the MAP kinase pathway.

So even if we could get a drug against a couple of kinases, the view was the early knockout mice of individual kinases

And one of the first laboratory experiments I did was I made a mutation in this kinase-- made it kinase inactive-- and it didn't work.

First of all, the prevailing view was you could never make a drug against a kinase.

So even if you shut down one kinase, the view was, you're going to kill people.

and then which ones had activation of this, what's called MAP kinase pathway, but due to upstream activation.

and a second drug called AZD7762, which is an inhibitor of a kinase-- or an enzyme, you could say-- within the cell that's

So the way I looked at it was, this is how kinases work, over there on the left.

His company's group at Novartis had synthesized a handful of drugs that seemed to shut down a variety of kinases.